In Vitro antileishmanial properties of neutron-irradiated meglumine antimoniate
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منابع مشابه
In Vitro Antileishmanial Properties of Neutron-Irradiated Meglumine Antimoniate
Pentavalent antimony, as meglumine antimoniate (Glucantime) or sodium stibogluconate (Pentostam), is the main treatment for leishmaniasis, a complex of diseases caused by the protozoan Leishmania, and an endemic and neglected threat in Brazil. Despite over half a century of clinical use, their mechanism of action, toxicity and pharmacokinetic data remain unknown. The analytical methods for de...
متن کاملFirst Report on Ototoxicity of Meglumine Antimoniate
INTRODUCTION Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. CASE REPORT A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold wit...
متن کاملHoigne Syndrome Caused by Intralesional Meglumine Antimoniate
Hoigne syndrome (HS) is the term coined to describe an acute, non-allergic, psychiatrically based reaction occurring with a wide list of medications, mainly antibiotics. Since its first description by Hoigne and Schoch in 1959, few cases have been reported in medical literature and, although antimicrobials are commonly used, very rarely in dermatology. The authors describe the first case occurr...
متن کاملComparison of meglumine antimoniate and pentamidine for peruvian cutaneous leishmaniasis.
Pentamidine was compared with meglumine antimoniate (Glucantime) for 80 patients with cutaneous leishmaniasis due to Leishmania braziliensis in Peru. Of the 40 patients administered Glucantime (20 mg of antimony [Sb]/kg/day intravenously for 20 days), 31 cured (78%), 6 failed (15%), of which 5 were due to relapse, and 3 were lost to follow-up (7%). Of the 40 patients administered pentamidine (2...
متن کاملNovel methods for the encapsulation of meglumine antimoniate into liposomes.
The antimonial drug, meglumine antimoniate, was successfully encapsulated in dehydration-rehydration vesicles and in freeze-dried empty liposomes (FDELs). High encapsulation efficiencies (from 28 to 58%) and low weight ratios of lipids to encapsulated antimony (from 1:0.15 to 1:0.3) were achieved. These formulations, contrary to those obtained by conventional methods, can be stored as intermedi...
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ژورنال
عنوان ژورنال: Brazilian Archives of Biology and Technology
سال: 2005
ISSN: 1516-8913
DOI: 10.1590/s1516-89132005000700009